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sustained growth-hormone-axis stimulation also carries a theoretical, class-wide concern for worsened insulin resistance, a recognized effect of excess growth hormone exposure generally Evidence snapshot: The strongest available evidence is a small 1997 randomized, placebo-controlled human trial (19 adults aged 55-71) testing a closely related GHRH(1-29) analog over 16 weeks, which found increased IGF-1 in both sexes, a significant lean-mass increase in men only, and increased skin thickness in both sexes

But that approach would need to be trialed and tested, McCoy says

Macular Edema : Another potential concern is the development of macular edema, a condition where fluid accumulates in the macula of the eye, leading to blurred or distorted vision

17.518 min 9095 % B

Researchers seeking sustained anabolic effects beyond 12 weeks typically transition to MK-677 during IGF-1 LR3 washout periods to maintain elevated growth factor signalling without overlapping receptor pathways

F., Whyte, B., Bissinger, P