glp 1 sanofi GLP-1 Drug Can Cause Rare, Potentially Blinding Side Effect, EMA Warns GI toxicity hits midstage Sanofi

Administration of an estrogen receptor antagonist was sufficient to blunt the effects of the central GLP-1 agonist on food reward behavior in both men and women

Side effects at the 12 mg level roughly doubled

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However, in the LookAHEAD study, an RCT comparing intensive lifestyle intervention (ILI) compared to best medical advice suggested a possible preventative effect on obesity-related cancers after 11 years, but this did not reach statistical significance (RR = 0.84, 95% CI = 0.681.04) [13]

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