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Ongoing Monitoring & Optimization Follow-up labs and outcome tracking

Early Research and Preclinical Studies Before tirzepatide could be tested in humans, scientists conducted preclinical studies

In a model of non-ischemic HF in dogs (tachycardiomyopathy induced by pacemakers), IV infusion of GLP-1 increases left ventricular (LV) contractility (LV dP/dt increased by 98%, stroke volume by 102%, and cardiac output by 57%) and decreases LV end-diastolic pressure, heart rate, and systemic vascular resistance

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The liver uses glutathione to tag these unwanted substances, making them water-soluble so the body can flush them out

Stabilization of methylene radicals by cob(II)alamin in coenzyme B12 dependent mutases