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A large amount of evidence has shown that long-term drinking disrupts the intestinal barrier function, leading to impaired integrity of tight junction proteins and increased intestinal permeability

It has also shown to exert protective effects on different experimental pathological situations, in which free radicals and ROS are involved, such as hyperacidity, parasites, constipation, musculoskeletal pain, arthritis, allergies, Ehlers-Dantos syndrome and immunomodulation [16, 17, 24]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Avella-Garcia CB, Julvez J, Fortuny J, Rebordosa C, Garcia-Esteban R, Galan IR, et al