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It shares approximately 94% structural homology with native human GLP-1 and has been widely studied in metabolic research for its role in glucose regulation, insulin secretion modulation, and appetite signalling pathways in laboratory and pre-clinical models

Metformin suppresses hepatic gluconeogenesis via AMPK activation, [6] while GLP-1 receptor agonists enhance glucose-dependent insulin secretion and promote satiety, improving both fasting and postprandial glycaemic control

Finally, adherence to the medication regimen is crucialmissed doses or inconsistent administration can reduce therapeutic efficacy

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