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"The real answer is: we don't know," emphasizes Hoffmeister

The solved crystal structure places the active site loop in a conformation which closely resembles the reduced `active state` of human succinic semialdehyde dehydrogenase

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The plasma pharmacokinetic parameters were calculated using baseline-corrected concentrations because quantifiable levels of endogenous NAC were detected at both baseline measurements (evening of Day 1 and pre-dose on Day 1)