Further enzymatic complexity is engendered by the functionally related DASH (dipeptidyl peptidase 4 activity and/or structure homologs) enzymes that replicate the enzymatic activity of DPP4 despite differences in structure and localization, thus explaining DPP4-like activity that persists after genetic deletion or pharmacological inhibition of DPP4 (24)
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In these populations, while LC supplementation increased TMAO levels, it was also associated with reduced markers of vascular injury and oxidative stress [27]
