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[12] [13] Established therapies remain the standard of care: topical treatments (corticosteroids, vitamin D analogues), phototherapy, conventional systemic agents (methotrexate, ciclosporin), and biological therapies targeting specific immune pathways (TNF- inhibitors, IL-17 inhibitors, IL-23 inhibitors)

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The following morning, body weight was measured, and a pre-dose blood sample was taken before participants received the last dose of the 5-week period, and repeated blood sampling was subsequently performed over the next 24 h for the PK analyses supporting evaluation of the co-primary endpoints

revealed that simvastatin intervention could antagonize the inhibitory effect of HFD on the expression of CYP7A1 in the liver tissue of rats (113)

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