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Brzozowski JS, Skelding KA

Studies in mice with CNS neuron-specific GLP-1R knockout showed that liraglutide failed to induce weight loss but still improved glucose levels, suggesting that brain GLP-1Rs are necessary for the weight-lowering effect of GLP-1RAs but not essential for their glucose-lowering effects (142)

A: Current evidence suggests these medications work best as long-term treatments

4.2 Others Cardiometabolic diseases revolve around the axis of insulin resistance and deficiency

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Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism