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Nanoparticles combined with radiotherapy or ICIs can also further enhance T cells recruitment in addition to the combination of PTT and PDT, such as the core-shell nanoparticle PLGA-R837@Cat prepared by encapsulating water-soluble catalase (Cat) and TLR7 agonist imiquimod (R837) in the PLGA shell can alleviate tumor hypoxia and modulate the immunosuppressive tumor microenvironment and not only recruit CD8 + CTLs and helper T cells into tumors and reduce the percentage of Tregs but also lead to higher CTLs infiltration in secondary tumors when combined with radiotherapy and CTLA-4 checkpoint blockade (CTLA4) to treat mouse tumors thereby inducing a strong anti-tumor immune response and effectively inhibiting tumor metastasis (189)

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