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A similar line of reasoning involves the kidney in the manifestations of the high-folatelow-vitamin B-12 interaction: depletion of serum vitamin B-12 may also be the result of preferential uptake of folic acid into the renal proximal tubule cells via FR-

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doi:10.1093/ajcn/80.6.1551 Funk RS, Jones J, Polireddy K, et al