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"These drugs have significant benefits, and so we should be finding a way to try and fund them, but it's really going to involve a lot of negotiations with the drug companies." The benefits to the economy as a whole are difficult to predict, Dr Karnon said, but he does believe there would be "some benefit"

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While these clinical studies documented only moderate and heterogeneous effects of GLP-1RAs on lean body mass, rodent studies have demonstrated a reduction of visceral adipose tissue and upregulation of browning-related genes in subcutaneous white adipose tissue, which can lead to a stimulation of energy expenditure by upregulated thermogenesis [79, 109, 110]