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Given GLP-1s role in your digestion, it makes sense that GLP-1 agonists like Ozempic cause gastrointestinal side effects like nausea, vomiting, and diarrhea

Histological evaluation revealed marked venous invasion

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Hypertension is multifactorial, influenced by genetics, environment, and other factors

So through different trial designs and populations, they helped me as an obesity medicine specialist really understand the biology of obesity, how to use these drugs, how to manage individuals on these drugs because of the GI side effects, and have hard outcomes that would actually lead to approval by the FDA