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We know that tirzepatide and semaglutide tip the scales towards a negative energy balance by lowering appetite and food intake. However, their acute and long-term effects on energy expenditure and metabolic adaptationsthe physiological adjustments the body makes to conserve energy in response to a reduction in calorie intakeafter treatment cessation remain poorly understood

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& Civelek, M

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The only available human clinical trial data comes from Beck et al