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Epidemiological data links chronically elevated IGF-1 levels above 300 ng/mL to increased colorectal and breast cancer risk (Renehan et al., Lancet 2004)

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Specifically, WG-treated HSC-T6 cells showed mitochondrial ridge breakdown and condensation, and WG alleviates liver fibrosis via enhancing ferroptosis in HSCs by regulating SLC7A11, GPX4, and GSH (Liu et al., 2022)