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It includes some heartburn medicines including proton pump inhibitors (PPIs) such as esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole, H2 blockers such as famotidine and certain diabetes medicines such as metformin

This treatment can also promote healthier hair, skin, and nails

The enzyme slows down how the body breaks down fat cells

Why This Matters for Health and Performance Understanding intrinsic factor physiology is crucial for recognizing conditions that can lead to B12 deficiency, including pernicious anemia (autoimmune destruction of parietal cells), gastric surgery, chronic PPI use, and various gastrointestinal disorders

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Insufficient intrinsic factor production, common in older adults due to age-related absorption decline, can also lead to deficiency