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The same reaction can occur on protein cysteine, and the formed GSNO group functions as important intermediate in NO metabolism, a critical player in fulfilling the biolgogical function of NO in signal transduction (Chung, 2006)

doi:10.1038/s41598-018-29313-w 96

For a patient with ME/CFS, this can feel identical to a severe post-exertional malaise (PEM) crash

Changes in the activities of antioxidant enzymes in response to virus infection and hormone treatment

However, a responsible medical discussion should distinguish between thymosin beta-4 research, TB-500 marketing claims, and the evidence needed to support patient care decisions