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This suggests it is cleared from the system quite rapidly, which has major implications for study design and dosing frequency

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While this reaction was traditionally viewed as a minor nicotinamide clearance pathway, research has revealed that NNMT activity has far-reaching consequences for cellular metabolism through multiple interconnected mechanisms

Vitamin B12 is necessary for the production of red blood cells, which help carry oxygen throughout the body

When NNMT activity is high, NAD+ is depleted, metabolic rate slows, and fat accumulation increases

It is essential not to confuse 'units' with milligrams or millilitres, as this is a well-recognised source of serious dosing error