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Tripeptide DT-109 (Gly-Gly-Leu) attenuates atherosclerosis and vascular calcification in nonhuman primates

If that sounds familiar, it's because the mechanism is similar to blood donation

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The Pro-Gly-Pro tail is chemically simple but functionally revolutionary: it blocks the carboxypeptidases that would otherwise destroy the peptide and allows enough residence time for nose-to-brain transport, receptor engagement, and downstream gene-expression effects

Bosch E, Espins JJ, Fabregues F, et al

Punwani 2012)