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[11] showed a greater reduction in body weight and HbA1c in patients using semaglutide plus SGLT-2i in comparison with monotherapy

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When addressing dimeric protein targets, the ability of dimeric therapeutic agents to antagonize paired receptors within a single molecular entity potentially offers superior therapeutic efficacy and target selectivity 15,16

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In a total of 6,571 patients with congenital nevi who were followed for a mean of 3.4 to 23.7 years, 46 patients (0.7%) developed 49 melanomas, a lower number than might have been expected, probably reflecting selection bias in published smaller studies

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