NICE technology appraisal TA875 (2023) recommends semaglutide 2.4 mg (Wegovy) as an adjunct to a reduced-calorie diet and increased physical activity for adults with a BMI of 35 kg/m or above (or 3034.9 kg/m in certain circumstances) alongside at least one weight-related comorbidity, when initiated within specialist weight management services
This matters in India specifically, since a large share of the population eats vegetarian and may get less dietary cysteine one of glutathione's building blocks than non-vegetarians
It's generally recommended to combine these two for their synergistic effects
Why that matters: cortisol and GLP-1 effectiveness are inversely linked, and perimenopausal estrogen decline dysregulates the HPA axis, raising baseline cortisol and driving hormonal belly fat redistribution that keeps women stuck at a normal BMI with real metabolic dysfunction
it's a human truth, really
In addition, pathway analysis identified arachidonic acid, glutathione, and nicotinate/nicotinamide metabolism as among the most significantly affected pathways