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Starting at a lower dose and advancing slowly gives your body time to adapt to the combination of reduced gallbladder function and slowed stomach emptying

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These symptoms can be mitigated by gradual dose escalation, ingestion of Metformin alongside meals, or the administration of extended-release preparations

Poor nutrition habits can lead to a number of consequences, including hypoglycemia, cardiovascular issues, and loss of muscle mass

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PMID 34159571