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A more profound knowledge on the pathogenesis, the natural history and risk of the progression, has enabled more differentiated therapy of elderly men with lower urinary tract symptoms due to benign prostatic hyperplasia as follows (Figure 3) [10, 11]

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Acholeplasma , Capnocytophaga , and Leptotrichia abundance decreased with rising SLEDAI scores, whereas Bacteroides , Ruminococcus , and Akkermansia levels declined with increasing serum C3 concentrations [20]