The reduction in biofilm formation, which is closely associated with the attenuation of bacterial virulence and diminished resistance to host defenses [31, 32], suggests that GR plays a important determinant beyond the oxidative stress response, influencing the ability of the bacterium to establish and maintain infections
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Clinical trials show moderate-to-large effects (e.g., 25-35% wrinkle/scar improvements), though limited by sample sizes and short durations
We define microdosing as any dose below the lowest commercially available starting dose
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