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However, despite their promising activity in pre-clinical models, HDIs have demonstrated only modest antitumour activity in initial clinical trials in solid malignancies

10.1016/j.molmet.2017.10.006 Mol

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Glutathione is one of our first lines of defense, a ubiquitous molecule, that is, present throughout our organism, but it is particularly concentrated at the liver level , where it protects the liver cells from toxic molecules: in this case, Glutathione "binds" to the toxic metabolites, neutralizing them

Treatment focuses on relieving symptoms with antihistamines or corticosteroids

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