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The 12-week escalation period is necessary for safety and tolerability

However, the TRIUMPH-1 Phase 3 trial results indicated significant weight loss, with participants losing up to 28.3% of their body weight at 80 weeks

Patients initiating GLP-1 therapy for diabetes or weight management who also experience joint pain should maintain a comprehensive approach to musculoskeletal health

Endogenous GLP-1 is rapidly degraded primarily by dipeptidyl peptidase-4 (DPP-4), as well as neutral endopeptidase 24.11 (NEP 24.11) and renal clearance, resulting in a half-life of approximately 2 minutes

doi: 10.3390/ijerph18084381

If your motivation is low or you have many different stressors in your life right now that are likely to interfere with your progress, it may not be the right time for a group program