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Clin Sci (2022) 136:168390

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The progesterone safety concern This is where things get serious

However, reports suggest that ROS can cause cytoskeletal remodeling in endothelial cells, leading to increased endothelial permeability due to altered calcium and cyclic adenosine monophosphate (cAMP) levels 27

Third, defining a safe therapeutic window is critical, and dose-ranging studies in humans are needed to balance efficacy and toxicity