7.5 Context-dependent functions and therapeutic implications The sirtuin family, specifically SIRT1, SIRT2, SIRT3, and SIRT7, exhibits context-dependent functions in modulating both the toxic and therapeutic effects of chemotherapeutic drugs
Del Prato et al., 2021)
However, the five-day half-life also means it takes time to reach steady-state concentrations
[1] [3] Key risk factors for developing hypotension on GLP-1 therapy include: Concurrent use of antihypertensive medications, especially diuretics, ACE inhibitors, or ARBs Concomitant use of SGLT2 inhibitors, which can cause osmotic diuresis and volume depletion Baseline blood pressure in the low-normal range (systolic 90-110 mmHg) Advanced age (65 years and older) Autonomic dysfunction or diabetic neuropathy Rapid or substantial weight loss Inadequate fluid intake or gastrointestinal side effects causing dehydration Concomitant use of other medications that lower blood pressure Patients with type 1 diabetes using off-label GLP-1 therapy or those with longstanding type 2 diabetes and cardiovascular autonomic neuropathy may be at higher risk for orthostatic hypotension
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