Previous studies have suggested weight-loss drugs may improve heart failure symptoms, but their effect on important outcomes such as hospitalisation and death has never been evaluated in large populations until now
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Schematic representation of the main pathophysiological mechanisms (lipotoxicity, oxidative stress, inflammation, and gut-liver axis) and therapies under evaluation directed at these processes, including THR- agonists, FGF-21 analogs, pan-PPAR modulators, GLP-1 RAs, and GLP-1/GIP combinations, in addition to conventional treatments such as SGLT-2 inhibitors, metformin, statins, and vitamin E
Studies have shown that patients using Semaglutide experience significant weight loss over 6 to 12 months, with some achieving reductions of up to 30% of their body weight
10.1158/0008-5472.can-08-3153 Cancer Res
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