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Symptom burden: multiple symptoms and their impact as patient-reported outcomes

In pivotal trials for semaglutide (Ozempic, Wegovy), fatigue was reported in roughly 510% of patients across dose levels, with most cases mild to moderate and resolving within weeks

Stacking not required

Specific event rates included nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)

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c-Fos expression associated with reinstatement of cocaine-seeking behavior by response-contingent conditioned cues