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In the citric acid cycle, the enzyme -ketoglutarate dehydrogenase requires TPP to convert -ketoglutarate into succinyl-CoA
Methylation genes tell us genetic predisposition but do not tell us phenotypic expression, which can be modulated by nutrient levels, gut health, toxic load, and use of methylation inhibitors (such as various drugs like PPIs, birth control pills, antibiotics, nitrous oxide, valproic acid, and cholestyramine)
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As with any medication, side effects are possible
This can lead to improved metabolic function, better stress response, and enhanced overall hormonal balance