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Metabolite annotation was performed based on an in-house library, and peak areas of 6-phosphogluconate, GSH, GSSG, NADPH, NADP + and UMP were analysed using Xcalibur software (ThermoFisher Scientific)

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In addition to its diabetes-related uses, Ozempic has gained off-label popularity as a weight-loss drug due to its ability to promote significant weight reduction

Compared to a placebo treatment, the daily orforglipron reduced body weight by an average of 12% after 72 weeks of treatment

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