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After 40, tendon quality naturally declines

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Neurological symptoms can include tingling or numbness in the hands and feet (peripheral neuropathy), a sensation often described as "pins and needles"

Body composition and histology DXA or EchoMRI for lean/fat mass, adipocyte morphometrics, and liver Oil Red O or lipidomics form a phenotypic core

NAD-boosting increased 4-6 fold the blood NAD + depending on individual, pointing to need of personalized dose adjustment in treatment trials

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