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In addition, CYP2E1 has high NADPH oxidase activity, which can induce NADH transport to mitochondria and increase the ROS production (Lu et al., 2010)

Nevertheless, monitoring remains essential because subtle symptoms may appear later during prolonged therapy

This timeline reports what the published trials and community sources describe across the first week, the two-to-four-week window, and the five-to-eight-week mark, then covers the factors that move the curve and what an absent response usually means

Once that foundation of understanding is in place, the decision about whether to move forward with the Playbook or Foundation becomes straightforward and low-risk

Moderator: - Peter Guthrey, Senior pharmacist - strategic policy, Pharmaceutical Society of Australia

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