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J Cancer Epidemiol (2013) 2013:965212

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To avoid AMP degradation engineered probiotic bacteria (lactic acid bacteria-LAB) that colonize the human intestinal tract were tested as a delivery vehicle

Human trials showed that in people with high-risk features, treatment with minocycline reduced in 6 months the risk of conversion to MS, decreased lesion volume, and showed the absence of new enhancing lesions, but this effect did not last beyond 24 months of study (Preiningerova et al., 2022)