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It is well established that the male gonads, along with hypothalamic gonadotropin releasing hormone (GnRH)-secreting neurons and pituitary gonadotroph cells, are highly sensitive to a wide range of influencesincluding genetic, environmental, chemical, and physical factorsthat may disrupt their proper development and function during critical windows such as gestation, the neonatal period, puberty, and the transitional age [1,2,3]

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Insulin intervention can stimulate the activity of HIF-1 and VEGF in retinal endothelial cells

Osteoporos Int 12:763768 Shires R, Aivioli LV, Bergfeld MA, Fallon MD, Slatopolsky E, Teitelbaum SL (1980) Effects of semistarvation on skeletal homeostasis