Cell Mol Life Sci 81(1):443 Donoso F et al (2023) Inflammation, lifestyle factors, and the microbiome-gut-brain axis: relevance to depression and antidepressant action
Molecular Structure of Semaglutide Semaglutide is a synthetic peptide of 31 amino acids, based on the natural GLP-1 hormone, with modifications that enhance stability and prolong its effect
Significance during GLP-1 therapy: Hyponatremia (low sodium levels) can occur during GLP-1 therapy due to increased fluid loss or dilutional effects
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Although GLP-1 receptors in the retina, ganglion cells and central nervous system play a neuroprotective role by suppressing neuroinflammationsuggesting no direct causalitythe rapid normalization of glycemic control and weight loss may disrupt pre-existing vascular stability, potentially increasing the risk of NAION, they wrote
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