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In a genetic preclinical study, embryonic GIPR knockout mice fed a high-fat diet were protected from obesity, supporting the role of GIPR antagonism as a method to promote weight loss and prevent weight gain (67)

Respiratory effects of treatment with a glucagon-like peptide-1 receptor agonist in patients suffering from obesity and chronic obstructive pulmonary disease

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doi: 10.1016/S0140-6736(19)31149-3

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Moving from overweight to normal weight restores energy, eliminates the subtle joint stress that accompanies excess weight, and often resolves early metabolic dysfunction before it progresses to disease