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Contributing factors involve hepatic de novo synthesis of cholesterol, reverse cholesterol transport generating HDL cholesterol [25], and hepatic uptake of intestinal chylomicrons

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Starting with high doses (1,000 mcg to 2,000 mcg) weekly or biweekly is common

-Mangostin protects against drug-induced acute liver injury by mitigating oxidative stress and suppressing inflammation

The most commonly reported adverse events in combination groups were nausea, vomiting, and constipation

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