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NHS access began in specialist weight management services from June 2025 for the highest-need patients, with tirzepatide prescribing incorporated into the GP Quality and Outcomes Framework from April 2026

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Phase 2 trial results, published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023), demonstrated that participants receiving the highest dose of retatrutide lost an average of approximately 24% of their body weight over 48 weeks a finding that attracted considerable attention from the medical and scientific communities

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