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1 Tolerability Semaglutide is generally well tolerated with similar dropout rates when compared with placebo, although it may be less well tolerated than dulaglutide (Trulicity)
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IV doses of 25-400 mcg/kg for safety studies Important: These are experimental doses used in animal studies and cannot be extrapolated to other species due to significant differences in metabolism, pharmacokinetics, receptor expression, peptide degradation rates, and tissue distribution patterns
Eligibility guidelines disqualify a significant number of people
Food and Drug Administration approved it in 2014 to help adults with obesity or adults who are overweight and who also have a weight-related health condition lose weight
GLP-1RAs attenuated obesity and reversed leptin resistance partly via activating the microbiome-derived inosine/A2A pathway
