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#ObesityManagement #Semaglutide #Wegovy #HealthcareInnovation #Pharma #PatientCare To view or add a comment, sign in MetaVia's obesity treatment candidate DA-1726 demonstrates weight loss and glycemic control in Phase 1 study MetaVia, an affiliate of Dong-A ST, reported on January 6 that its Phase 1 clinical trial evaluating the maximum tolerated dose of DA-1726(development code), a glucagon-like peptide 1(GLP-1)/glucagon(GCG) dual agonist under development for the treatment of obesity, demonstrated excellent outcomes, including pronounced weight loss, improvements in glycemic control, and a decrease in liver stiffness

However, with the exception of istradefylline, almost all of the other clinical trials with novel therapeutics have failed in recent years, including preladenant, vipadenant, and the nonxanthine SCH58261 [59,60]

The major advantage of this approach is that small molecules have a considerable higher bioavailability compared to antibodies, dominant-negative receptors and antisense oligonucleotides