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Patients with: Personal or family history of Medullary thyroid cancer MEN2 syndrome Severe gastroparesis Pregnancy/ breastfeeding Pancreatitis or breastfeeding Severe depression Eating disorders Liver or kidney disease (caution advised) Why GLP-1 and Inflammation and Arthritis Matter We now understand that GLP-1 medications are not just weight loss drugs. They are anti-inflammatory, immune-modulating, metabolic medications that can dramatically shift health outcomes for patients with arthritis and autoimmune diseases

Where were investing our time and capital Supply Change Capitals broader health thesis around personalized solutions that make it easy for people to eat according to their nutrition and dietary needs aligns well with the opportunities arising in GLP-1 companion products

While the timeline includes it as part of the combination drug Qsymia (approved in 2012), phentermine on its own was approved by the FDA much earlier, back in 1959, for short-term use (typically up to 12 weeks)

Decreasing ectopic lipid accumulation also may promote insulin sensitivity [13]

Your body is adjusting

References [1] Eli Lilly and Company