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doi: 10.1016/j.molmet.2019.09.010 90 MojsovSWeirGCHabenerJF

These transmembrane enzymes utilize NADPH to reduce O 2 , directly producing H 2 O 2 (as by NOX4, DUOX1/2) [72] or indirectly via O 2 generation (by NOX1-3) [73], which rapidly dismutates to H 2 O 2

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