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Clinical studies show Tirzepatide can lead to significant weight loss for many individuals

Melatonin treatment has downregulated and upregulated CDK1 and p21 in GC cell lines, respectively [165]

That particular study found that at the 86-week mark, most if not all participants had put back all of their lost weight except for 3 pounds

GLP-1RA or dual GIP/GLP-1RA added to basal insulin compared to basal insulin titrated with a rigorous intention-to-treat approach is moderately effective in preventing further increase in daily basal insulin dose from achieving treat-to-target glycemic goals ( daily insulin dose, SMD -0.49, 95% CI -0.71

However, it could be worth switching medications, to see if your body reacts differently to another type