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It is, however, considered appropriate for older adults or individuals with limited exercise tolerance and reduced physical capacity (124)

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Following treatment with You-Gui-Wan, a reversal in the composition of the intestinal microbiota was noted, accompanied by a restoration of metabolite levels including acetylcarnitine, tryptophan, n-leucine, isoleucine, betaine, methionine, and valine (Hsu et al., 2021), and it may reduce Der p-induced inflammation and regulate Th1/ Th2 immune disorders by down-regulating TGF- , IL-4, IL-5, IL-13 and inhibiting NF-B activation and up-regulating IL-12 (Lin et al., 2012)

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Mitochondria were maloriented in two patients and degeneration of membranous organelles was seen in three cases