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Reducing Inflammation Chronic inflammation in the gastrointestinal (GI) tract is a major contributor to conditions like IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), or gut damage from ibuprofen and naproxen use
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Alteration of substrate specificity of microbial TyrA enzymes provides another example of a single active site residue that modifies substrate specificity of plant and microbial enzymes (Louie et al., 2006
Phase 2 cagrilintide alone ~10.8% body weight reduction at 26 weeks (4.5mg) Phase 2 CagriSema combo ~15.6% body weight reduction at 32 weeks Phase 3 REDEFINE 1 ~22.7% body weight reduction at 68 weeks Phase 2 CagriSema combination trial The Phase 2 trial of CagriSema was published in The Lancet in 2023, and its results attracted immediate attention
This kind of activation promotes tumour -supporting microenvironments and drives metastatic colonization by promoting epithelial-mesenchymal transition and extracellular matrix remodelling [60, 61]
