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Furthermore, PPIA was also upregulated in the secretome of H 2 O 2 -exposed chondrocytes and a receptor for this protein (BSG) was upregulated at 16 h post-exposure to stress [87]

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Five clinical trials (SURPASS 1-5 trials) conducted in patients with T2DM showed that tirzepatide at 5-15 mg per week could reduce body weight (5.4-11.7kg), which was never seen with a single drug (129)

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