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PUFA-PE production depends on coordinated action between acyl coenzyme A synthetase long-chain family member 4 (ACSL4) and lysophospholipid acyltransferase 3 (LPCAT3), which collectively activate and incorporate PUFAs (e.g., docosahexaenoic acid, arachidonic acid) into membrane lipids (43)

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The role of IGF1R in DDR includes promotion of DNA repair