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"Reaction mechanism of glutathione synthetase from Arabidopsis thaliana: site-directed mutagenesis of active site residues"

The mechanisms by which metabolic syndrome leads to kidney disease are not completely understood, but inflammation, insulin resistance, oxidative stress, and dysfunction of the small blood vessels of the kidney are involved (Raimundo 2011)

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[3] The proposed mechanism involves B12 altering the gene expression of skin bacteria ( Cutibacterium acnes ), leading to increased inflammatory compounds